Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
R Ito, Y Ohno, Y Mu, Y Ka, S Ito, M Emi-Sugie… - 2023 - researchsquare.com
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable for
exploring human hematology and immunology. However, sufficient recapitulation of human …
exploring human hematology and immunology. However, sufficient recapitulation of human …
Foe turned friend: multiple functional roles attributable to hyper‐activating stem cell factor receptor mutant in regeneration of the haematopoietic cell compartment
S Pati, OP Kalra, A Mukhopadhyay - Cell Proliferation, 2011 - Wiley Online Library
Objectives: Stem cell factor receptor, c‐kit, is considered to be the master signalling
molecule of haematopoietic stem cells. It develops the orchestral pattern of haematopoietic …
molecule of haematopoietic stem cells. It develops the orchestral pattern of haematopoietic …
Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
S Okada, H Nakauchi, K Nagayoshi, S Nishikawa… - 1991 - ashpublications.org
The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor for stem cell
factor (SCF). The c-kit/SCF signal is expected to have an important role in hematopoiesis. A …
factor (SCF). The c-kit/SCF signal is expected to have an important role in hematopoiesis. A …
[HTML][HTML] Stem cell activity of porcine c-kit+ hematopoietic cells
AC Le Guern, MA Giovino, M Abe, PR Theodore… - Experimental …, 2003 - Elsevier
Objective. A marker for hematopoietic stem cells (HSCs) of pigs, which are considered to be
the most suitable donors for clinical xenotransplantation, has not yet been identified. In this …
the most suitable donors for clinical xenotransplantation, has not yet been identified. In this …
[HTML][HTML] Enhanced and accelerated repopulation of mutant c-kit immunodeficient mice by transplants of primary chronic and acute myeloid leukemic human cells
N Nakamichi, CA Hammond, PH Miller, K Rothe… - Blood, 2016 - Elsevier
Background: Assessment of the growth and differentiation of human hematopoietic cells
transplanted into immunodeficient mice has become an important method for evaluating the …
transplanted into immunodeficient mice has become an important method for evaluating the …
Kit Deficiency Regulates Stable Human Hematopoietic Stem Cell Engraftment in Mice
Humanized mice are required for in-depth analysis of human hematopoietic stem cell (HSC)
function and immunobiology. The currently available options are problematic because …
function and immunobiology. The currently available options are problematic because …
[HTML][HTML] A novel kit mutant rat enables hematopoietic stem cell engraftment without irradiation
R Iida, S Ishida, J Wang, K Hattori, K Yoshimi… - Experimental …, 2024 - Elsevier
Hematopoietic stem cell (HSC) transplantation is extensively studied in mouse models, but
their limited scale presents challenges for effective engraftment and comprehensive …
their limited scale presents challenges for effective engraftment and comprehensive …
c-kit<low Pluripotent Hemopoietic Stem Cells Form CFU-S on Day 16
Z Lian, B Feng, K Sugiura, M Inaba, C Yu, T Jin… - Stem Cells, 1999 - academic.oup.com
Using Ly5 congenic mice, we characterized the early differentiation step of pluripotent
hemopoietic stem cells. Lineage−(Lin−)/CD71− cells in the bone marrow cells were …
hemopoietic stem cells. Lineage−(Lin−)/CD71− cells in the bone marrow cells were …
[HTML][HTML] Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice
PH Miller, G Rabu, M MacAldaz, DJHF Knapp… - Experimental …, 2017 - Elsevier
Highlights•A 900 cGy low dose rate 137 Cs gamma irradiation optimally conditions adult
NRG mice.•High human chimerism is obtained in Sirpα NOD RG-W 41 homozygotes given …
NRG mice.•High human chimerism is obtained in Sirpα NOD RG-W 41 homozygotes given …
[PDF][PDF] Nonirradiated NOD, B6. SCID Il2rγ−/− KitW41/W41 (NBSGW) mice support multilineage engraftment of human hematopoietic cells
BE McIntosh, ME Brown, BM Duffin, JP Maufort… - Stem cell reports, 2015 - cell.com
In this study, we demonstrate a newly derived mouse model that supports engraftment of
human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD. Cg …
human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD. Cg …