Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a
propensity for increased levels following toxic insult. Although more than 20 base lesions …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism.
Furthermore, despite protective mechanisms, cellular levels of damage may increase under …

Research of the role of oxidative DNA damage is well established in experimental
carcinogenesis. A large number of human studies on biomarkers of oxidative DNA damage …

Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly
elevated levels of such lesions do not always result in cancer remain elusive. Much of the …

DNA damage is any modification to the structure of DNA that alters its coding properties
and/or interferes with cell processes. One major consequence of oxidative stress is DNA …

Since DNA is prone to oxidative attack cells have evolved multiple protective strategies to
prevent the deleterious effects of DNA oxidation. Base excision repair is the major …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

Oxidative-stress-induced damage to DNA includes a multitude of lesions, many of which are
mutagenic and have multiple roles in cancer and aging. Many lesions have been …