Antibiotics are often used in neonates despite the absence of relevant dosing information in
drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and …

Introduction: For safe and effective neonatal antibiotic therapy, knowledge of the
pharmacokinetic parameters of antibacterial agents in neonates is a prerequisite. Fast …

Dosing of antibiotics in neonates requires finding a delicate balance between maximal
efficacy and minimal toxicity. There is a lack of data on efficacy of currently used antibiotics …

Infection is common in premature infants and can cause significant morbidity and mortality.
To prevent these devastating consequences, most infants admitted to the neonatal intensive …

Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

Rational medicine use in neonates implies the prescription and administration of age-
appropriate drug formulations, selecting the most efficacious and safe dose, all based on …

Objectives: Neonates are not just little children. They need more finesse in decisions on
when to treat, which antibiotics to use and how to dose these antibiotics. Methods …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …