Genetic and epigenetic basis of hepatoblastoma diversity

G Nagae, S Yamamoto, M Fujita, T Fujita… - Nature …, 2021 - nature.com
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary
predisposition and acquired molecular aberrations related to HB clinicopathological …

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

M Eichenmüller, F Trippel, M Kreuder, A Beck… - Journal of …, 2014 - Elsevier
Background & Aims Hepatoblastoma (HB) is the most common childhood liver cancer and
occasionally presents with histological and clinical features reminiscent of hepatocellular …

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

J Carrillo-Reixach, L Torrens, M Simon-Coma… - Journal of …, 2020 - Elsevier
Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

M Sekiguchi, M Seki, T Kawai, K Yoshida… - NPJ precision …, 2020 - nature.com
Although hepatoblastoma is the most common pediatric liver cancer, its genetic
heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a …

[PDF][PDF] Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

P Sumazin, Y Chen, LR Treviño, SF Sarabia… - …, 2017 - Wiley Online Library
Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare
neoplasm. Consequently, few pretreatment tumors have been molecularly profiled, and …

[PDF][PDF] Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex

D Jia, R Dong, Y Jing, D Xu, Q Wang, L Chen, Q Li… - …, 2014 - Wiley Online Library
Hepatoblastoma (HB) is the most common primary liver tumor in children. Mutations in the β‐
catenin gene that lead to constitutive activation of the Wnt pathway have been detected in a …

Genetics and epigenetics of hepatoblastoma

GE Tomlinson, R Kappler - Pediatric blood & cancer, 2012 - Wiley Online Library
A number of unique genetic features are observed in hepatoblastoma that have provided
insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in …

The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis

A Zimmermann - European Journal of Cancer, 2005 - Elsevier
The identification of distinct types and subtypes of hepatoblastoma has led to a successful
classification of these lesions. In recent years, and particularly within large tumour trials, the …

Hepatic stem-like phenotype and interplay of Wnt/β-catenin and Myc signaling in aggressive childhood liver cancer

S Cairo, C Armengol, A De Reyniès, Y Wei, E Thomas… - Cancer cell, 2008 - cell.com
Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-
catenin signaling. Here, we used microarray analysis to identify two tumor subclasses …

[HTML][HTML] Novel advances in understanding of molecular pathogenesis of hepatoblastoma: a Wnt/β-catenin perspective

D Bell, S Ranganathan, J Tao, SP Monga - Gene expression, 2017 - ncbi.nlm.nih.gov
Hepatoblastoma is the most common pediatric liver malignancy, typically striking children
within the first 3 years of their young lives. While advances in chemotherapy and newer …