Small vessel disease is a stroke subtype characterized by pathology of the small perforating
arteries, which supply the sub-cortical structures of the brain. Small vessel disease is …

Objective To investigate whether white matter network disruption underlies the pathogenesis
of apathy, but not depression, in cerebral small vessel disease (SVD). Methods Three …

Objective To determine the prevalence of apathy and depression in cerebral small vessel
disease (SVD), and the relationships between both apathy and depression with cognition …

Objective: To determine whether cerebral small-vessel disease (SVD) is a specific risk factor
for depression, whether any association is mediated via white matter damage, and to study …

Objective To determine whether apathy or depression predicts all-cause dementia in small
vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of …

Patients with small vessel cerebrovascular disease frequently suffer from apathy, a
debilitating neuropsychiatric syndrome, the underlying mechanisms of which remain to be …

Objective Depressive symptoms are common in elderly with cerebral small vessel disease
(SVD). As not every individual with SVD experiences depressive symptoms, other factors …

Small vessel pathology and microvascular lesions are no longer considered as minor
players in the fields of cognitive impairment and mood regulation. Although frequently found …

Background Cerebral small vessel disease, a common cause of vascular dementia, is often
considered clinically silent before dementia or stroke become apparent. However, some …

Few studies have applied multiple imaging modalities to examine cognitive correlates of
white matter. We examined the utility of T2-weighted magnetic resonance imaging (MRI) …