Using epigenetic clocks to characterize biological aging in studies of children and childhood exposures: A systematic review

RJ Musci, RS Raghunathan, SB Johnson, L Klein… - Prevention …, 2023 - Springer
Biological age, measured via epigenetic clocks, offers a unique and useful tool for
prevention scientists to explore the short-and long-term implications of age deviations for …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

S Marini, KA Davis, TW Soare, Y Zhu… - …, 2020 - Elsevier
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …

Assessment of epigenetic clocks as biomarkers of aging in basic and population research

ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …

Epigenetic clocks and research implications of the lack of data on whom they have been developed: a review of reported and missing sociodemographic …

SH Watkins, C Testa, JT Chen, I De Vivo… - Environmental …, 2023 - academic.oup.com
Epigenetic clocks are increasingly being used as a tool to assess the impact of a wide
variety of phenotypes and exposures on healthy ageing, with a recent focus on social …

Statistical and conceptual considerations in socioepigenomics research on childhood adversity and epigenetic aging

EC Dunn, AJ Simpkin, E Walton - JAMA Network Open, 2023 - jamanetwork.com
Applications of epigenetic clocks to health questions have proliferated over the past decade,
particularly as a means of understanding disease etiology. Epigenetic clocks are aggregate …

Epigenetic clocks in the pediatric population: when and why they tick?

J Wang, WH Zhou - Chinese Medical Journal, 2021 - mednexus.org
Recent research efforts have provided compelling evidence of genome-wide DNA
methylation alterations in pediatrics. It is currently well established that epigenetic clocks …

Epigenetic clock: A promising biomarker and practical tool in aging

R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

R methylCIPHER: a methylation clock investigational package for hypothesis-driven evaluation & research

KL Thrush, AT Higgins-Chen, Z Liu, ME Levine - biorxiv, 2022 - biorxiv.org
Background Epigenetic clocks are promising tools for the study of aging in humans. The
clocks quantify biological aging above and beyond chronological age, demonstrate …

“Epigenetic clocks”: Theory and applications in human biology

CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …