In recent years, cancer genomics has provided new insights into genetic alterations and
signaling pathways involved in thyroid cancer. However, the picture of the molecular …

Thyroid cancer is a heterogeneous disease with several subtypes characterized by
cytological, histological and genetic alterations, but the involvement of epigenetics is not …

Context Even though the majority of well-differentiated thyroid carcinoma (WDTC) is
indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests …

Objective: The purpose of this study was to determine the global patterns of aberrant DNA
methylation in thyroid cancer. Research Design and Methods: We have used DNA …

Context: Aberrant DNA methylation is known to be a major factor in oncogenesis and cancer
progression, but effects of methylation in papillary thyroid cancer (PTC) are not well defined …

Aberrant gene methylation plays an important role in human tumorigenesis, including
thyroid tumorigenesis. Many tumor suppressor genes are aberrantly methylated in thyroid …

Background Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a
recent increase in incidence in many countries. Although PTC has been explored by gene …

DNA methylation is one of the essential epigenetic mechanisms that are closely correlated
with the mechanisms underlying cell growth, differentiation and transformation in …

DNA methylation is the best-studied epigenetic mechanism for regulating gene transcription
and maintaining genome stability. Current research progress of transcriptional regulation by …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …