Coenzyme A (CoA) biosynthesis is an excellent target for antimalarial intervention. While
most studies have focused on the use of CoA to produce acetyl-CoA in the apicoplast and …

The malaria parasite Plasmodium falciparum depends on glucose to meet its energy
requirements during blood-stage development. Although glycolysis is one of the best …

Malaria parasites retain a relict plastid (apicoplast) from a photosynthetic ancestor. The
apicoplast is a useful drug target but the specificity of compounds believed to target …

Pantothenate, a precursor of the fundamental enzyme cofactor coenzyme A (CoA), is
essential for growth of the intraerythrocytic stage of human and avian malaria parasites …

We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a
druggable target, using genetic and chemical validation. In vitro evolution of resistance with …

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both …

The malaria parasite Plasmodium falciparum possesses a unique Acetyl-CoA Synthetase
(PfACS), which provides acetyl moieties for different metabolic and regulatory cellular …

Lysine acetylation has emerged as a major post‐translational modification involved in
diverse cellular functions. Using a combination of immunoisolation and liquid …

Mitochondria of the malaria parasite Plasmodium falciparum are morphologically different
between the asexual and sexual blood stages (gametocytes). In this paper recent findings of …

Background The carbon metabolism of the blood stages of Plasmodium falciparum,
comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be …