[HTML][HTML] The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria

DB Kell, EL Heyden, E Pretorius - Frontiers in immunology, 2020 - frontiersin.org
Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

Time to kill and time to heal: the multifaceted role of lactoferrin and lactoferricin in host defense

A Ohradanova-Repic, R Praženicová, L Gebetsberger… - Pharmaceutics, 2023 - mdpi.com
Lactoferrin is an iron-binding glycoprotein present in most human exocrine fluids,
particularly breast milk. Lactoferrin is also released from neutrophil granules, and its …

Lactoferrin: balancing ups and downs of inflammation due to microbial infections

ME Drago-Serrano, R Campos-Rodríguez… - International journal of …, 2017 - mdpi.com
Lactoferrin (Lf) is a glycoprotein of the primary innate immune-defense system of mammals
present in milk and other mucosal secretions. This protein of the transferrin family has broad …

Lactoferrin for the treatment of COVID‑19

Y Wang, P Wang, H Wang, Y Luo… - Experimental and …, 2020 - spandidos-publications.com
Abstract The coronavirus disease 2019 (COVID‑19) outbreak was caused by infection with
the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The clinical outcomes …

Lactoferrin: An overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance

M Sienkiewicz, A Jaśkiewicz, A Tarasiuk… - Critical reviews in food …, 2022 - Taylor & Francis
Lactoferrin (LF), a glycoprotein found in mucosal secretions, is characterized by a wide
range of functions, including immunomodulatory and anti-inflammatory activities. Moreover …

Lactoferrin as potential preventative and adjunct treatment for COVID-19

R Chang, TB Ng, WZ Sun - International Journal of Antimicrobial Agents, 2020 - Elsevier
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic is rapidly advancing
across the globe despite drastic public and personal health measures. Antivirals and …

The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19

JK Mann, T Ndung'u - Future Virology, 2020 - Future Medicine
Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is
spreading rapidly with no established effective treatments. While most cases are mild, others …

[HTML][HTML] Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin

M Miotto, L Di Rienzo, L Bò, A Boffi… - Frontiers in molecular …, 2021 - frontiersin.org
Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has
rapidly become pandemic, mainly due to its extremely high human-to-human transmission …

[HTML][HTML] Potential lactoferrin activity against pathogenic viruses

EM Redwan, VN Uversky, EM El-Fakharany… - Comptes rendus …, 2014 - Elsevier
Abstract Lactoferrin (LF) is an 80-kDa globular glycoprotein with high affinity for metal ions,
particularly for iron. This protein possesses many biological functions, including the binding …

Lactoferrin and its derived peptides: An alternative for combating virulence mechanisms developed by pathogens

D Zarzosa-Moreno, C Avalos-Gómez… - Molecules, 2020 - mdpi.com
Due to the emergence of multidrug-resistant pathogens, it is necessary to develop options to
fight infections caused by these agents. Lactoferrin (Lf) is a cationic nonheme multifunctional …