Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been
extensively studied and is poorly understood. Our work describes a posttranscriptional …

Abstract Interleukin-8 (IL-8) is a neutrophil chemotactic and activating cytokine that is
produced in response to several stimuli. Because monocytic cells are important producers of …

We investigated the role of IL-12 in regulating IL-2 and IFN-γ production in primary culture of
human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA …

Double stranded RNA (dsRNA), an intermediate that is common during viral infection,
directly induces much higher levels of expression of interleukin‐6 (IL‐6) mRNA than does …

Interferon-gamma (IFN-γ), also known as type II interferon, is an important immunoregulatory
gene that has multiple effects on the development, maturation, and function of the immune …

Interferon-γ (IFN-γ) is a multifunctional cytokine that defines the development of Th1 cells
and is critical for host defense against intracellular pathogens. IL-2 is another key …

Alpha/beta interferons (IFN-α/β), including the single IFN-β and a large group of IFN-α
isotypes, represent an essential element of host defense against viruses and other …

Nmi and IFP35 are interferon (IFN)-induced proteins. In cells treated with IFN-γ, Nmi
enhances the association of transcription co-activator CBP/p300 with signal transducer and …

Many cytokines and growth factors trigger rapid changes in gene expression upon binding
to their receptors. In many cases, the mechanism by which these changes are affected is …

We have developed small peptide mimetics of gamma interferon (IFNgamma), based not on
the classical model of IFNgamma initiated signaling by extracellular interaction, but rather on …