Essential hypertension is a complex clinical condition, characterized by multiple and
concomitant abnormal activation of different regulatory and contra-regulatory …

Effective treatment of high blood pressure (BP) represents a key strategy for reducing the
burden of hypertension-related cardiovascular and renal diseases. In spite of these well …

The increasing prevalence of hypertension, owing to modern lifestyles and the increasing
elderly population, is contributing to the global burden of cardiovascular (CV) disease …

In all actual clinical guidelines, dihydropyridine calcium channel blockers (CCBs) belong to
the recommended first line antihypertensive drugs to treat essential hypertension. Several …

Dihydropyridine calcium channel antagonists have been maligned in recent years because
of concerns regarding their cardiovascular and overall safety profile. Specifically, it was …

Background: Dihydropyridine calcium channel blockers are a heterogeneous group of
antihypertensive drugs. Long-acting dihydropyridine agent amlodipine is widely used for …

Blood pressure (BP) control is central to health promotion and maintenance across the
health care continuum. Optimal control has been associated with improved microvascular …

Calcium channel blockers (CCBs) constitute a heterogeneous class of drugs that can be
divided into dihydropyridines (DHPs) and non-DHPs. DHP-CCBs are subcategorized into …

In a meta-analysis published in June 2003, we reported that new and old classes of
antihypertensive drugs had similar long-term efficacy and safety. Furthermore, we observed …

Outcome with Nifedipine GITS (ACTION) study in which nifedipine GITS was compared with
placebo, significant reductions of 28% and 27% were seen the incidence of any stroke or …