Homocysteine (Hcy), a cardiovascular and neurovascular disease risk factor, is converted to
hydrogen sulfide (H2S) through the transsulfuration pathway. H2S has attracted …

While the role of hyperhomocysteinemia in cardiovascular pathogenesis continuously draws
attention, deficiency of hydrogen sulfide (H2S) has been growingly implicated in …

Deficiencies of the human cystathionine β-synthase (CBS) enzyme are characterized by a
plethora of vascular disorders and hyperhomocysteinemia. However, several clinical trials …

Homocysteine, a cardiovascular and neurocognitive disease risk factor, is converted to
hydrogen sulfide, a cardiovascular and neuronal protectant, through the transsulfuration …

Although there is a growing recognition of the significance of hydrogen sulfide (H 2 S) as a
biological signaling molecule involved in vascular and nervous system functions, its …

HC metabolism and vascular dysfunction. HC is formed upon demethylation of methionine
via S-adenosylmethionine (AdoMet) and S-adenosylhomocysteine (AdoHC). HC is …

Elevated plasma levels of homocysteine are a risk factor for cardiovascular diseases, neural
tube defects, and Alzheimer's disease. The transsulfuration pathway converts homocysteine …

Molecular defects in genes encoding enzymes involved in homocysteine metabolism may
account for mild hyperhomocysteinaemia, an independent and graded risk factor for …

An inborn error of metabolism, homocystinuria due to cystathionine β-synthase deficiency,
results in markedly elevated levels of circulating homocysteine. Premature vascular events …

Severely elevated plasma homocysteine (Hcy) levels observed in genetic disorders of Hcy
metabolism are associated with pathologies in multiple organs and lead to premature death …