Role of brown fat in lipoprotein metabolism and atherosclerosis

G Hoeke, S Kooijman, MR Boon, PCN Rensen… - Circulation …, 2016 - Am Heart Assoc
Atherosclerosis, for which hyperlipidemia is a major risk factor, is the leading cause of
morbidity and mortality in Western society, and new therapeutic strategies are highly …

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

JFP Berbée, MR Boon, PPSJ Khedoe, A Bartelt… - Nature …, 2015 - nature.com
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma
triglyceride levels and reducing obesity. However, the precise role of BAT in plasma …

A new, powerful player in lipoprotein metabolism: brown adipose tissue

A Bartelt, M Merkel, J Heeren - Journal of molecular medicine, 2012 - Springer
Important causes for modern epidemics such as obesity, diabetes, and cardiovascular
disease are over-and malnutrition. Dietary as well as endogenous lipids are transported …

Brown fat fuel utilization and thermogenesis

KL Townsend, YH Tseng - Trends in Endocrinology & Metabolism, 2014 - cell.com
Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis
and to contribute to energy expenditure in rodents and possibly humans. The energetic …

Fatty acid metabolism and the basis of brown adipose tissue function

M Calderon-Dominguez, JF Mir, R Fucho, M Weber… - Adipocyte, 2016 - Taylor & Francis
Obesity has reached epidemic proportions, leading to severe associated pathologies such
as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue …

Brown adipose tissue and lipid metabolism

J Heeren, L Scheja - Current opinion in lipidology, 2018 - journals.lww.com
Brown adipose tissue and lipid metabolism : Current Opinion in Lipidology Brown adipose tissue
and lipid metabolism : Current Opinion in Lipidology Log in or Register Subscribe to …

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation [S]

P Kotzbeck, A Giordano, E Mondini, I Murano… - Journal of lipid …, 2018 - ASBMB
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose
tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes …

The whitening of brown fat and its implications for weight management in obesity

I Shimizu, K Walsh - Current obesity reports, 2015 - Springer
Systemic inflammation resulting from dysfunction of white adipose tissue (WAT) accelerates
the pathologies of diabetes and cardiovascular diseases. In contrast to WAT, brown adipose …

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

PPSJ Khedoe, G Hoeke, S Kooijman, W Dijk… - Journal of lipid …, 2015 - ASBMB
Brown adipose tissue (BAT) produces heat by burning TGs that are stored within
intracellular lipid droplets and need to be replenished by the uptake of TG-derived FA from …

New powers of brown fat: fighting the metabolic syndrome

J Nedergaard, T Bengtsson, B Cannon - Cell metabolism, 2011 - cell.com
An understanding of the full powers of brown adipose tissue (BAT) is only successively
being accumulated. In a paper in Nature Medicine, Bartelt et al.(2011) add further …