The normal contractile function of vascular smooth muscle cells (SMCs) and elastin lamellae
in media layer, are keys for aorta to withstand hemodynamic stress. Abdominal aortic …

Abdominal aortic aneurysm (AAA) is characterized by aorta dilation due to wall
degeneration, which mostly occurs in elderly males. Vascular aging is implicated in …

Aortic aneurysm (AA) and dissection (AD) are aortic diseases caused primarily by medial
layer degeneration and perivascular inflammation. They are lethal when the rupture …

Rationale: Abdominal aortic aneurysms (AAA) are characterized by aortic enlargement and
underlying weakness of the vessel wall. Experimental and clinical evidence suggests that …

Objectives Aortic aneurysm and dissection (AAD) are vascular disorders with high mortality
and no effective pharmaceutical treatments. Previous evidence has suggested an elevated …

Cyclic nucleotides regulate a wide variety of processes in vascular smooth muscle cells
(SMCs) from short-term action in smooth muscle relaxation to long-term processes such as …

VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging,
hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit …

Proliferation of arterial smooth muscle cells (SMCs) is a key event in the formation of
advanced atherosclerotic lesions and restenosis after angioplasty. Cyclic nucleotides (cAMP …

Numerous laboratories have each investigated phosphodiesterase expression in contractile
and synthetic vascular smooth muscle cells isolated from several species including human …

Smooth muscle cells (SMCs) in the arterial wall are normally found in a contractile,
nonproliferative state. These SMCs are continuously exposed to agents that elevate cyclic …