Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

D Wang, H Wu, SZF Phua, G Yang, W Qi Lim… - Nature …, 2020 - nature.com
Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy
(PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) …

A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced …

D Wang, H Wu, WQ Lim, SZF Phua, P Xu… - Advanced …, 2019 - Wiley Online Library
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as
the local oxygen concentration plays an important role in the generation of cytotoxic singlet …

A cerium oxide@ metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

J Liu, LY Ye, WH Xiong, T Liu, H Yang… - Chemical …, 2021 - pubs.rsc.org
An O2 self-evolving core–shell theranostic nanohybrid was developed by encapsulating a
nanoenzyme cerium oxide (CeOx) in a metal–organic framework (MOF). The hybrid reveals …

Nanozyme decorated metal–organic frameworks for enhanced photodynamic therapy

Y Zhang, F Wang, C Liu, Z Wang, LH Kang, Y Huang… - ACS …, 2018 - ACS Publications
Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of
cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by …

Metal–Organic Framework-Supported Catalase Delivery for Enhanced Photodynamic Therapy via Hypoxia Mitigation

Y Sim, J Seong, S Lee, D Kim, E Choi… - … Applied Materials & …, 2023 - ACS Publications
Tumor hypoxia poses a significant challenge in photodynamic therapy (PDT), which uses
molecular oxygen to produce reactive oxygen species upon light excitation of a …

An All‐in‐One Organic Semiconductor for Targeted Photoxidation Catalysis in Hypoxic Tumor

W Chen, Z Sun, C Jiang, W Sun, B Yu… - Angewandte …, 2021 - Wiley Online Library
Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT).
Although many methods for oxygen generation exist, substantial safety concerns …

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

X Yang, Y Yang, F Gao, JJ Wei, CG Qian, MJ Sun - Nano letters, 2019 - ACS Publications
Nanozymes as artificial enzymes that mimicked natural enzyme-like activities have received
great attention in cancer diagnosis and therapy. Biomimetic nanozymes require more …

Bimetallic Ions Functionalized Metal–Organic‐Framework Nanozyme for Tumor Microenvironment Regulating and Enhanced Photodynamic Therapy for Hypoxic …

MM Pan, P Li, YP Yu, M Jiang, X Yang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT), as a light irradiation inducing reactive oxygen species (ROS)
generation for cancer treatment, offers facile and promising solutions with respect to …

Catalase Nanocrystals Loaded with Methylene Blue as Oxygen Self‐Supplied, Imaging‐Guided Platform for Photodynamic Therapy of Hypoxic Tumors

R Zhou, TY Ohulchanskyy, H Xu, R Ziniuk, J Qu - Small, 2021 - Wiley Online Library
Photodynamic therapy (PDT) is a well‐known method for cancer therapy in the clinic.
However, the inherent hypoxia microenvironment of solid tumors enormously restricts the …

Biodegradable calcium phosphate nanotheranostics with tumor‐specific activatable cascade catalytic reactions‐augmented photodynamic therapy

LH Fu, Y Wan, C Li, C Qi, T He, C Yang… - Advanced Functional …, 2021 - Wiley Online Library
Photodynamic therapy (PDT) is exploited as a promising strategy for cancer treatment.
However, the hypoxic solid tumor and the lack of tumor‐specific photosensitizer …