Cell-to-cell variability in the timing of cell-fate changes can be advantageous for a
population of single-celled organisms growing in a fluctuating environment. We study timing …

Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid
gametes. Meiotic differentiation and cell growth (proliferation) are mutually exclusive …

The IME1 gene is essential for initiation of meiosis in the yeast Saccharomyces cerevisiae,
although it is not required for growth. Here we report that in stationary-phase cultures …

Cells have evolved oscillators with different frequencies to coordinate periodic processes.
Here we studied the interaction of two oscillators, the cell division cycle (CDC) and the yeast …

Diploid yeast cells switch from mitosis to meiosis when starved of essential nutrients. While
G 1 cyclins play a key role in initiating the mitotic cell cycle, entry into meiosis depends on …

The genes required for meiosis and sporulation in yeast are expressed at specific points in a
highly regulated temporal pathway. Recent experiments using DNA microarrays to examine …

Initiation of meiosis in Saccharomyces cerevisiae is regulated by mating type and nutritional
conditions that restrict meiosis to diploid cells grown under starvation conditions …

We carried out a population genomic survey of Saccharomyces cerevisiae diploid isolates
and find that many budding yeast strains have high levels of genomic heterozygosity, much …

Yeast cells enter and undergo gametogenesis relatively asynchronously, making it
technically challenging to perform stage-specific genomic and biochemical analyses. Cell-to …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …