Being able to limit the pursuit of reward to prevent negative consequences is an important
expression of behavioral inhibition. Everyday examples of an inability to exert such control …

Rationale Excessive intake of rewards, such as food and drugs, often has explicit negative
consequences, including the development of obesity and addiction, respectively. Thus …

BACKGROUND: Corticolimbic circuits, including direct projections from prefrontal cortex to
nucleus accumbens (NAc), permit top-down control of intense motivations generated by …

The rodent dorsal medial prefrontal cortex (PFC), specifically the prelimbic cortex (PL),
regulates the expression of conditioned fear and behaviors interpreted as reward seeking …

The risk of an aversive consequence occurring as the result of a reward‐seeking action can
have a profound effect on subsequent behavior. Such aversive events can be described as …

The involvement of different nodes within meso-cortico-limbic-striatal circuitry in mediating
reward-seeking has been well described, yet comparatively less is known about how such …

Suppression of ill-timed or competing actions optimizes goal-directed behaviors. Diminished
inhibitory control over such actions is a central feature of such disorders as impulsivity …

From an evolutionary perspective the startle eye-blink response forms an integral part of the
human avoidance behavioral repertoire and is typically diminished by pleasant emotional …

Flexible initiation or suppression of actions to avoid aversive events is crucial for survival.
The prelimbic (PL) and infralimbic (IL) regions of the medial prefrontal cortex (mPFC) have …

Rationale Control of reward-seeking behavior under conditions of punishment is an
important function for survival. Objectives and methods We designed a task in which rats …