[HTML][HTML] White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

A Garnier-Crussard, S Bougacha, M Wirth… - Alzheimer's research & …, 2020 - Springer
Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …

Neuropathologic correlates of white matter hyperintensities in a community-based cohort of older adults

K Arfanakis, AM Evia, SE Leurgans… - Journal of …, 2020 - content.iospress.com
Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …

The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition

M Dadar, R Camicioli, S Duchesne… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction Cognitive decline in Alzheimer's disease is associated with amyloid
beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the …

The effect of white matter hyperintensities on cognition is mediated by cortical atrophy

B Rizvi, A Narkhede, BS Last, M Budge, G Tosto… - Neurobiology of …, 2018 - Elsevier
White matter hyperintensities (WMH) have been linked to cognitive dysfunction and
dementia, although the reasons are unclear. One possibility is that WMH promote …

Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function

AC Birdsill, RL Koscik, EM Jonaitis, SC Johnson… - Neurobiology of …, 2014 - Elsevier
White matter hyperintensities (WMH) of presumed vascular origin, as seen on T2-weighted
fluid attenuated inversion recovery magnetic resonance imaging, are known to increase with …

White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia

M Dadar, AL Manera, S Ducharme, DL Collins - Neurobiology of aging, 2022 - Elsevier
White matter hyperintensities (WMHs) are commonly assumed to represent non-specific
cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a …

Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns

L Pålhaugen, CH Sudre, S Tecelao… - Journal of Cerebral …, 2021 - journals.sagepub.com
White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer's
disease. In this study, we examined relations between WMH load and distribution, amyloid …

White matter abnormalities and cognition in a community sample

TD Vannorsdall, SR Waldstein, M Kraut… - Archives of clinical …, 2009 - academic.oup.com
White matter hyperintensities (WMH) can compromise cognition in older adults, but
differences in sampling, WMH measurements, and cognitive assessments contribute to …

[HTML][HTML] Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

A Brugulat-Serrat, G Salvadó, CH Sudre… - Brain imaging and …, 2020 - Springer
White matter hyperintensities (WMH) are commonly detected in the brain of elderly
individuals and have been associated with a negative impact on multiple cognitive domains …

Associations of white matter hyperintensities with cognitive decline: a longitudinal study

YL Wang, W Chen, WJ Cai, H Hu, W Xu… - Journal of …, 2020 - content.iospress.com
White matter hyperintensities (WMHs), mainly caused by cerebrovascular injury, may lead to
cognitive impairment. In order to identify whether the volume of WMHs is associated with …