A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …

Background An accumulating body of evidence is consistent with the hypothesis that
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD is
characterized by progressive neuronal degeneration that is accompanied by the formation of …

Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …

Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …

Background: P38 mitogen activated protein kinase (MAPK) α modulates microglia-mediated
inflammatory responses and a number of neuronal physiological processes. Objective: To …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …