Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

cis-Diamminedichloroplatinum (II)(cisplatin) is among the most active antitumour agent used
in human chemotherapy. The purpose of this review is to give an insight in several …

Although cisplatin, cis-diamminedichloroplatinum (II), has been successfully used in the
chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA
and forms 1, 2-d (ApG), 1, 2-d (GpG) and 1, 3-d (GpTpG) intrastrand crosslinks, interstrand …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …

Platinum‐based compounds are widely used as chemotherapeutics for the treatment of a
variety of cancers. The anticancer activity of cisplatin and other platinum drugs is believed to …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …