Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

Cirrhosis is a form of liver fibrosis resulting from chronic hepatitis and caused by various liver
diseases, including viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, and …

Abstract β‑catenin, a core component of Wnt/β‑catenin signaling, has been shown to be an
important regulator of cellular proliferation and differentiation. Abnormal activation of Wnt/β …

The Wnt signaling pathway is an evolutionarily conserved, highly complex signaling
pathway that is critical for development, differentiation and cellular homeostasis. The protein …

Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic …

The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Wnt/β‐catenin signaling is emerging as a forerunner for its critical roles in many facets of
human biology. Its roles in embryogenesis, organogenesis, and maintaining tissue and …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …

The liver is uniquely bestowed with an ability to regenerate following a surgical or toxicant
insult. One of the most researched models to demonstrate the regenerative potential of this …