Is serotonin uptake by peripheral tissues sensitive to hypoxia exposure?

MHB Amador, MD McDonald - Fish physiology and biochemistry, 2022 - Springer
Abstract In the Gulf toadfish (Opsanus beta), the serotonin (5-HT) transporter (SERT) is
highly expressed in the heart, and the heart and gill both demonstrate the capacity for SERT …

Mild hypoxia exposure impacts peripheral serotonin uptake and degradation in Gulf toadfish (Opsanus beta)

J Sebastiani, A Sabatelli… - Journal of Experimental …, 2022 - journals.biologists.com
ABSTRACT Plasma serotonin (5-hydroxytryptamine, 5-HT) homeostasis is maintained
through the combined processes of uptake (via the 5-HT transporter SERT, and others) …

The serotonin transporter and nonselective transporters are involved in peripheral serotonin uptake in the Gulf toadfish, Opsanus beta

MHB Amador, MD McDonald - American Journal of …, 2018 - journals.physiology.org
In mammals, circulating serotonin [5-hydroxytryptamine (5-HT)] is sequestered by platelets
via the 5-HT transporter (SERT) to prevent unintended signaling by this potent signaling …

The role of uptake and degradation in the regulation of peripheral serotonin dynamics in Gulf toadfish, Opsanus beta

J Sebastiani, MD McDonald - … and Physiology Part A: Molecular & …, 2021 - Elsevier
Abstract The neurotransmitter serotonin (5-hyroxytryptamine, 5-HT) is involved in a variety of
peripheral processes. Arguably most notable is its role as a circulating vasoconstrictor in the …

Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4

MHB Amador, MD McDonald - Journal of Experimental …, 2018 - journals.biologists.com
The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-
HT) from the extracellular milieu and is the molecular target of the selective serotonin re …

The paracrine role of 5-HT in the control of gill blood flow

B Pelster, T Schwerte - Respiratory Physiology & Neurobiology, 2012 - Elsevier
Storage of serotonin in teleost gill cells has been detected in neurons, polymorphous
granular cells and in neuroepithelial cells. Innervation from the glossopharyngeal nerve (first …

Turnover of serotonin in brain of an anoxia-tolerant vertebrate, the crucian carp

GE Nilsson - American Journal of Physiology-Regulatory …, 1990 - journals.physiology.org
Serotonin (5-HT) is a neurotransmitter in the vertebrate brain. Estimates of 5-HT turnover
times range between 1 h (mammals) and 10 h (goldfish). Synthesis and catabolism of 5-HT …

Effects of Serotonin on Circulation and Respiration in the Rainbow Trout Oncorhynchus Mykiss

R Fritsche, S Thomas, SF Perry - Journal of experimental …, 1992 - journals.biologists.com
The effects of serotonin (5-hydroxytryptamine; 5-HT) on continuously recorded dorsal and
ventral aortic blood pressures,(PDA, PVA), arterial oxygen tension arterial carbon dioxide …

Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response

JM Panlilio, S Marin, MB Lobl, MD McDonald - Scientific Reports, 2016 - nature.com
The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of
the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5 …

Central ventilatory and cardiovascular actions of serotonin in trout

M Kermorgant, F Lancien, N Mimassi… - Respiratory Physiology & …, 2014 - Elsevier
This study was undertaken to investigate the central actions of 5-HT on ventilatory and
cardiovascular variables in the unanesthetized trout. Compared to vehicle …