[HTML][HTML] Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to …
K Nguyen, C Dobrowolski, M Shukla, WK Cho… - PLoS …, 2021 - journals.plos.org
One strategy for a functional cure of HIV-1 is “block and lock”, which seeks to permanently
suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter …
suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter …
[HTML][HTML] Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
K Imai, H Togami, T Okamoto - Journal of Biological Chemistry, 2010 - ASBMB
Elucidating the mechanism of human immunodeficiency virus, type 1 (HIV-1) provirus
transcriptional silencing in latently infected cells is crucial for understanding the …
transcriptional silencing in latently infected cells is crucial for understanding the …
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2
J Friedman, WK Cho, CK Chu, KS Keedy… - Journal of …, 2011 - Am Soc Microbiol
Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …
H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells
MK Tripathy, MEM McManamy, BD Burch… - Journal of …, 2015 - Am Soc Microbiol
Histone methyltransferase inhibitors (HMTis) and histone deacetylase inhibitors (HDACis)
are reported to synergistically induce the expression of latent human immunodeficiency …
are reported to synergistically induce the expression of latent human immunodeficiency …
UTX-1 regulates Tat-induced HIV-1 transactivation via changing the methylated status of histone H3
HS Zhang, GY Du, Y Liu, ZG Zhang, Z Zhou, H Li… - … International Journal of …, 2016 - Elsevier
Epigenetic modifications are thought to be important for gene expression changes during
HIV-1 transcription and replication. The removal of histone H3 lysine27 (H3K27) …
HIV-1 transcription and replication. The removal of histone H3 lysine27 (H3K27) …
[HTML][HTML] The histone methyltransferase SETD2 regulates HIV expression and latency
CR Bussey-Sutton, A Ward, JA Fox, AMW Turner… - PLoS …, 2024 - journals.plos.org
Understanding the mechanisms that drive HIV expression and latency is a key goal for
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …
Multiple histone lysine methyltransferases are required for the establishment and maintenance of HIV-1 latency
We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2)
is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the …
is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the …
[HTML][HTML] Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
Understanding the mechanism of HIV-1 latency is crucial to eradication of the viral reservoir
in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like …
in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like …
Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients
S Bouchat, JS Gatot, K Kabeya, C Cardona, L Colin… - Aids, 2012 - journals.lww.com
Objective: Reactivation of HIV-1 expression in persistent reservoirs together with an efficient
HAART has been proposed as an adjuvant therapy aimed at reaching a functional cure for …
HAART has been proposed as an adjuvant therapy aimed at reaching a functional cure for …
[HTML][HTML] YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
S N'Da Konan, E Ségéral, F Bejjani, M Bendoumou… - Retrovirology, 2022 - Springer
Background The recent discovery of the role of m6A methylation in the regulation of HIV-1
replication unveiled a novel layer of regulation for HIV gene expression. This …
replication unveiled a novel layer of regulation for HIV gene expression. This …
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- hiv reactivation h3k27 demethylase
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- involvement of histone hiv 1
- methylated status utx 1
- methyltransferase enhancer hiv 1
- h3k9 dimethylation hiv 1
- hiv proviruses h3k27 demethylase
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- latent hiv h3k27 demethylation