Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice

AS Smith, AC Korgan, WS Young - Pharmacological research, 2019 - Elsevier
Intranasal delivery of oxytocin (Oxt) has been identified as a potential therapeutic to target
human conditions characterized by social deficits, yet the ability of this administrative route …

Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

SM Freeman, S Samineni, PC Allen… - …, 2016 - Elsevier
Oxytocin (OT) is a neuropeptide that mediates a variety of complex social behaviors in
animals and humans. Intranasal OT has been used as an experimental therapeutic for …

Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice

ID Neumann, R Maloumby, DI Beiderbeck… - …, 2013 - Elsevier
The possibility to improve socio-emotional behaviors in humans by intranasal administration
of synthetic oxytocin (OXT) attracts increasing attention, but its uptake into the brain has …

[HTML][HTML] Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …

Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

DS Quintana, KT Smerud, OA Andreassen… - Therapeutic …, 2018 - Future Science
The neuropeptide oxytocin plays an evolutionarily conserved role in mammalian social
behavior. Despite striking effects on animal social behavior after intracerebroventricular drug …

[HTML][HTML] Chronic and acute intranasal oxytocin produce divergent social effects in mice

H Huang, C Michetti, M Busnelli, F Manago… - …, 2014 - nature.com
Intranasal administration of oxytocin (OXT) might be a promising new adjunctive therapy for
mental disorders characterized by social behavioral alterations such as autism and …

[HTML][HTML] CSF and blood oxytocin concentration changes following intranasal delivery in macaque

O Dal Monte, PL Noble, J Turchi, A Cummins… - PloS one, 2014 - journals.plos.org
Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior,
making it a candidate for treating clinical disorders such as schizophrenia and autism …

[HTML][HTML] Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

[HTML][HTML] Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

N Striepens, KM Kendrick, V Hanking, R Landgraf… - Scientific reports, 2013 - nature.com
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin
on human social cognition and behaviour, however as yet no study has actually …

[HTML][HTML] Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

DA Martins, N Mazibuko, F Zelaya… - Nature …, 2020 - nature.com
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …