Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Objectives Stretch affects vascular smooth muscle cell proliferation and apoptosis, and
several responsible genes have been proposed. We tested whether the expression of …

Background—Accumulating evidence suggests that C-reactive protein (CRP), in addition to
being a predictor of coronary events, may have direct actions on the vessel wall in the …

Angiotensin II (AngII) has been strongly implicated in hypertension and its complications.
Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances …

Aging of the vasculature is characterized by endothelial dysfunction and arterial stiffening,
two key events in the pathogenesis of cardiovascular disease (CVD). Treatment with sodium …

2 Hypertension May 2018 acknowledged in VSMCs, whether it has any significance in
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …

Rationale: Possible beneficial effects of GDF11 (growth differentiation factor 11) on the
normal, diseased, and aging heart have been reported, including reversing aging-induced …

Aims Cardiac fibrosis is a major cause of heart failure (HF), and mediated by the
differentiation of cardiac fibroblasts into myofibroblasts. However, limited tools are available …

Background—New vessel formation contributes to organ development during
embryogenesis and tissue repair in response to mechanical damage, inflammation, and …

Background—Excessive stimulation of Gq protein–coupled receptors by cognate
vasoconstrictor agonists induces a variety of cardiovascular processes, including …