[HTML][HTML] A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
J Mannion, V Gifford, B Bellenie, W Fernando… - Immunity, 2024 - cell.com
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress
sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD) …
sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD) …
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death
J Clucas, P Meier - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cell death and inflammation are closely linked arms of the innate immune response to
combat infection and tissue malfunction. Recent advancements in our understanding of the …
combat infection and tissue malfunction. Recent advancements in our understanding of the …
Linear ubiquitination of RIPK1 on Lys612 regulates systemic inflammation via preventing cell death
Abstract Receptor-interacting protein kinase-1 (RIPK1) is a master regulator of the TNF-α–
induced cell death program. The function of RIPK1 is tightly controlled by posttranslational …
induced cell death program. The function of RIPK1 is tightly controlled by posttranslational …
[HTML][HTML] RIPK1 prevents aberrant ZBP1-initiated necroptosis
Receptor interacting protein kinase 1 (RIPK1) regulates inflammation and cell death, in host
defense and homeostasis. The adaptor function of RIPK1 allows pro-survival and …
defense and homeostasis. The adaptor function of RIPK1 allows pro-survival and …
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine
kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8 …
kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8 …
K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death through its
kinase activity. However, how its kinase activity is regulated remains poorly understood …
kinase activity. However, how its kinase activity is regulated remains poorly understood …
RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of inflammation and cell
death. Many sites on RIPK1, including serine 25, are phosphorylated to inhibit its kinase …
death. Many sites on RIPK1, including serine 25, are phosphorylated to inhibit its kinase …
Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity
AG Snyder, NW Hubbard, MN Messmer… - Science …, 2019 - science.org
Although the signaling events that induce different forms of programmed cell death are well
defined, the subsequent immune responses to dying cells in the context of cancer remain …
defined, the subsequent immune responses to dying cells in the context of cancer remain …
[PDF][PDF] Targeting RIPK1, 2, 3 to combat inflammation
A Bullock, A Degterev - Oncotarget, 2015 - ora.ox.ac.uk
Receptor Interacting Protein Kinases (RIPKs) are a seven member family of human dual
specificity (Ser/Thr and Tyr) kinases. Several members of this family, namely RIPK1, RIPK2 …
specificity (Ser/Thr and Tyr) kinases. Several members of this family, namely RIPK1, RIPK2 …
The death-inducing activity of RIPK1 is regulated by the pH environment
K Moriwaki, S Balaji, F Ka-Ming Chan - Science signaling, 2020 - science.org
Receptor-interacting protein kinase 1 (RIPK1) is a serine/threonine kinase that dictates
whether cells survive or die in response to the cytokine tumor necrosis factor (TNF) and …
whether cells survive or die in response to the cytokine tumor necrosis factor (TNF) and …