High-risk breast lesions, which comprise benign lesions and in situ carcinomas (lobular
carcinoma in situ and ductal carcinoma in situ), are clinically, morphologically, and …

Numerous models have been developed to quantify the combined effect of various risk
factors to predict either risk of developing breast cancer, risk of carrying a high-risk germline …

Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …

Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH),
ductal carcinoma in situ (DCIS), and lobular neoplasia (LN). There is a significant debate …

Purpose The increased breast cancer risk conferred by a diagnosis of lobular carcinoma in
situ (LCIS) is poorly understood. Here, we review our 29-year longitudinal experience with …

Rapidly increasing incidence of breast cancer is a new social challenge resulting from a
spectrum of internal and external risk factors which appear to be well accepted as an …

Atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) are nonmalignant breast
lesions that confer a 4-to 10-fold increased risk for breast cancer in women. Often, AH and …

Most types of invasive breast cancer are thought to evolve over long periods from specific
preexisting benign lesions. Of the many types of benign entities found in the human breast …

BRCA1/2 mutation carriers have a considerably increased risk to develop breast and
ovarian cancer. The personalized clinical management of carriers and other at-risk …

Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …