NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors
M Hayashi, A Kuga, M Suzuki, H Panda, H Kitamura… - Cancer Research, 2020 - AACR
The transcription factor Nrf2 activates transcription of cytoprotective genes during oxidative
and electrophilic insults. Nrf2 activity is regulated by Keap1 in a stress-dependent manner in …
and electrophilic insults. Nrf2 activity is regulated by Keap1 in a stress-dependent manner in …
A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer
EJ Choi, BJ Jung, SH Lee, HS Yoo, EA Shin, HJ Ko… - Oncogene, 2017 - nature.com
The Kelch-like ECH-associated protein 1 (KEAP1)–nuclear factor E2-related factor 2 (NRF2)
pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or …
pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or …
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular
adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in …
adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in …
Dysfunctional KEAP1–NRF2 interaction in non-small-cell lung cancer
A Singh, V Misra, RK Thimmulappa, H Lee… - PLoS …, 2006 - journals.plos.org
Background Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive
transcription factor that positively regulates the expression of genes encoding antioxidants …
transcription factor that positively regulates the expression of genes encoding antioxidants …
“NRF2 addiction” in lung cancer cells and its impact on cancer therapy
Nuclear factor erythroid 2-like factor 2 (NRF2) is a master regulator of the antioxidant
enzymes and the detoxification proteins that play major roles in redox homeostasis …
enzymes and the detoxification proteins that play major roles in redox homeostasis …
[HTML][HTML] KEAP1-Mutant NSCLC: the catastrophic failure of a cell-protecting hub
Mutations in the KEAP1-NRF2 pathway are common in NSCLC, albeit with a prevalence of
KEAP1 mutations in lung adenocarcinoma and an equal representation of KEAP1 and …
KEAP1 mutations in lung adenocarcinoma and an equal representation of KEAP1 and …
Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
M Gong, Y Li, X Ye, L Zhang, Z Wang, X Xu… - Cell Communication and …, 2020 - Springer
Background and purpose Targeted therapy and immunotherapy have led to dramatic
change in the treatment of lung cancer, however, the overall 5-year survival rate of lung …
change in the treatment of lung cancer, however, the overall 5-year survival rate of lung …
NRF2 as a regulator of cell metabolism and inflammation in cancer
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …
Dissecting the crosstalk between NRF2 signaling and metabolic processes in cancer
JM DeBlasi, GM DeNicola - Cancers, 2020 - mdpi.com
Simple Summary The stress-responsive transcription factor NRF2 (nuclear factor-erythroid 2
p45-related factor 2) directs cellular metabolic processes that can have diverse effects in the …
p45-related factor 2) directs cellular metabolic processes that can have diverse effects in the …