Aging intersects with reproductive senescence in women by promoting a systemic low-grade
chronic inflammation that predisposes women to several diseases including ovarian cancer …

In middle-aged women, the decline of ovarian follicle reserve below a critical threshold
marks menopause, leading to hormonal, inflammatory, and metabolic changes linked to …

The fertility of women declines sharply after age 35 and is essentially lost upon menopause
at age 51. The ovary plays an important part in aging-associated changes in women's …

The mammalian female is born with a limited ovarian reserve of primordial follicles. These
primordial follicles are slowly activated throughout the reproductive lifecycle, thereby …

Ovarian cancer (OC) incidence and mortality peaks at post-menopause while OC risk is
either reduced by parity or increased by nulliparity during fertile life. The long-term effect of …

This study shows that lack of ovarian activity has a negative impact on the life span of female
mice. The extent to which this phenomenon could be associated with the anti-inflammatory …

Aging is universal and underlies chronic disease as well as tissue and cellular deterioration.
The female reproductive system is the first to age in humans, with functional decline …

Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased
chronic disease burden. These effects begin to emerge long before follicular exhaustion …

Reproductive ageing in females is defined by a progressive decline in follicle number and
oocyte quality. This is a natural process that leads to the loss of fertility and ovarian function …

Female fertility is negatively correlated with age, with noticeable declines in oocyte quantity
and quality until menopause. To understand this physiological process and evaluate human …