Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial
membrane potential, and DNA fragmentation are apoptosis markers found in human …

Introduction 3. Germ Cell Apoptosis 4. Sperm Apoptosis 5. Apoptosis in cryptorchid testis 6.
Oxidative stress and apoptosis 7. Apoptosis and male infertility 8. Apoptosis and male …

OBJECTIVE: To evaluate ejaculated spermatozoa from patients with male factor infertility for
the role of cytochrome c and caspases 9 and 3 (the proteins known to mediate apoptosis) …

Reactive oxygen species (ROS) is one of the most common causatives of male infertility. At
normal physiological levels, ROS mediate essential physiological roles to ensure proper …

Oxygen, in its diatomic form, is essentially reduced to sustain cellular respiration and
survival. This reduction leads to generation of highly reactive oxygen metabolites or reactive …

Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

All living aerobic cells are normally exposed to some reactive oxygen species (ROS) but if
ROS levels rise, oxidative stress (OS) occurs, which results in oxygen and oxygen-derived …

Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …

One of the major causes of defective sperm function is oxidative stress, which not only
disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a …

Sperm is particularly susceptible to reactive oxygen species (ROS) during critical phases of
spermiogenesis. However, the level of seminal ROS is restricted by seminal antioxidants …