Organ-specific autoimmune diseases such as oophoritis, gastritis, thyroiditis, and orchitis
were induced in female or male nude (nu/nu) mice by the transfer of nu/+ spleen cells from …

Autoimmune diseases appeared frequently in adults in the prostate and stomach of C3. 129
mice after thymectomy on day 3 (Tx-3) without any additional treatment. Lesions of both …

Neonatal splenocytes, neonatal thymocytes, or phenotypically mature adult thymocytes,
transferred from normal BALB/c mice to syngeneic athymic nu/nu (or SCID) mice, led to …

BALB/c athymic nu/nu mice spontaneously developed organ-specific (gastritis, thyroiditis,
oophoritis, or orchitis) and systemic (arteritis, glomerulonephritis, and polyarthritis) …

This paper shows that elimination of a small subpopulation of peripheral T cells can elicit
activation/expansion of self-reactive T cells from the remaining T cells and produce a wide …

Autoimmune prostatitis developed spontaneously in (C57BL/6N x A/J) F1 (B6A) mice, when
thymectomy (Tx) was conducted on day 3 after birth (Tx-3). The lesion could be prevented by …

An important question is how the immune system can control the behavior of autoimmune
effector lymphocytes. My colleagues and I have investigated this question in four models …

In 1973 two groups reported the induction of organ-specific autoimmune diseases by T cell
deprivation. Penhale and co-workers (Penhale et al. 1973) found that autoimmune thyroiditis …

The administration of soluble mouse thyroglobulin (MTg) in conjunction with bacterial
lipopolysaccharide (LPS) led to the termination of natural tolerance to MTg in mice. The …

We have shown that spontaneously occurring, organ-specific autoimmune lesions develop
in aged C57BL/6 mice of both sexes, especially in 24-month-old senescent mice. The …