We recently showed that patients with different chronic pain conditions (such as chronic low
back pain, fibromyalgia, migraine and Gulf War illness) demonstrated elevated brain and/or …

Numerous preclinical studies support the role of spinal neuroimmune activation in the
pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)-or macrophage …

Although substantial evidence has established that microglia and astrocytes play a key role
in the establishment and maintenance of persistent pain in animal models, the role of glial …

Psychological and personality factors, socioeconomic status, and brain properties all
contribute to chronic pain but have essentially been studied independently. Here, we …

Various peripheral and spinal mechanisms have been hypothesized to contribute to pain
amplification and chronicity. However, the role of the brain in chronic pain states remains to …

Recent evidence highlights the importance of the neuroimmune interface, including
periphery-to-central nervous system (CNS) neuroimmune crosstalk, in chronic pain …

Thalamic neuroinflammation as a reproducible and discriminat... : PAIN Thalamic
neuroinflammation as a reproducible and discriminating signature for chronic low back pain …

Inflammation plays a role in neuropathic pain conditions as well as in pain induced solely by
an inflammatory stimulus. Robust mechanical hyperalgesia and allodynia can be induced by …

Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is
known about the mechanism underlying pain-comorbid NA, previous studies have …

The aim of the study was to identify inflammatory cytokines/chemokines associated with
neuroinflammation and periphery-to-CNS inflammatory cross-talk in degenerative disc …