Critical overview of the use of Ru (II) polypyridyl complexes as photosensitizers in one-photon and two-photon photodynamic therapy

F Heinemann, J Karges, G Gasser - Accounts of chemical …, 2017 - ACS Publications
Conspectus Photodynamic Therapy (PDT) is an emerging technique to treat certain types of
cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different …

[HTML][HTML] Dual mode of cell death upon the photo-irradiation of a Ru II polypyridyl complex in interphase or mitosis

V Pierroz, R Rubbiani, C Gentili, M Patra, C Mari… - Chemical …, 2016 - pubs.rsc.org
Photodynamic therapy (PDT) is an attractive, complementary medical technique to
chemotherapy. Among the different photosensitizers (PSs) employed, Ru (II) polypyridyl …

Rationally designed long-wavelength absorbing Ru (II) polypyridyl complexes as photosensitizers for photodynamic therapy

J Karges, F Heinemann, M Jakubaszek… - Journal of the …, 2020 - ACS Publications
The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer
has gained increasing attention over the last decades. Despite the clinical success of …

Evaluation of the medicinal potential of two ruthenium (II) polypyridine complexes as one‐and two‐photon photodynamic therapy photosensitizers

J Hess, H Huang, A Kaiser, V Pierroz… - … A European Journal, 2017 - Wiley Online Library
Abstract Two [Ru (phen) 2dppz] 2+ derivatives (phen= 1, 10‐phenantroline, dppz= dipyrido
[3, 2‐a: 2′, 3′‐c] phenazine) with different functional groups on the dppz ligand [dppz‐7, 8 …

[HTML][HTML] Rationally designed ruthenium complexes for 1-and 2-photon photodynamic therapy

J Karges, S Kuang, F Maschietto, O Blacque… - Nature …, 2020 - nature.com
The use of photodynamic therapy (PDT) against cancer has received increasing attention
over recent years. However, the application of the currently approved photosensitizers (PSs) …

Synthesis, characterization, and biological evaluation of new Ru (II) polypyridyl photosensitizers for photodynamic therapy

A Frei, R Rubbiani, S Tubafard, O Blacque… - Journal of medicinal …, 2014 - ACS Publications
Two Ru (II) polypyridyl complexes, Ru (DIP) 2 (bdt)(1) and [Ru (dqpCO2Me)(ptpy)]
2+(2)(DIP= 4, 7-diphenyl-1, 10-phenanthroline, bdt= 1, 2-benzenedithiolate, dqpCO2Me= 4 …

DNA Intercalating RuII Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

C Mari, V Pierroz, R Rubbiani, M Patra… - … A European Journal, 2014 - Wiley Online Library
Six substitutionally inert [RuII (bipy) 2dppz] 2+ derivatives (bipy= 2, 2′‐bipyridine, dppz=
dipyrido [3, 2‐a: 2′, 3′‐c] phenazine) bearing different functional groups on the dppz …

Mechanisms of action of Ru (II) polypyridyl complexes in living cells upon light irradiation

M Jakubaszek, B Goud, S Ferrari… - Chemical communications, 2018 - pubs.rsc.org
The unique photophysical properties of Ru (II) polypyridyl complexes make them very
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …

Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

E Wachter, DK Heidary, BS Howerton… - Chemical …, 2012 - pubs.rsc.org
Incorporation of biquinoline ligands into Ru (II) polypyridyl complexes produces light-
activated systems that eject a ligand and photobind DNA after irradiation with visible and …