Epilepsy as a dynamic disease: A Bayesian model for differentiating seizure risk from natural variability
Objective A fundamental challenge in treating epilepsy is that changes in observed seizure
frequencies do not necessarily reflect changes in underlying seizure risk. Rather, changes in …
frequencies do not necessarily reflect changes in underlying seizure risk. Rather, changes in …
Is seizure frequency variance a predictable quantity?
DM Goldenholz, SR Goldenholz, R Moss… - Annals of clinical …, 2018 - Wiley Online Library
Background There is currently no formal method for predicting the range expected in an
individual's seizure counts. Having access to such a prediction would be of benefit for …
individual's seizure counts. Having access to such a prediction would be of benefit for …
Markov modelling of treatment response in a 30-year cohort study of newly diagnosed epilepsy
People with epilepsy have variable and dynamic trajectories in response to antiseizure
medications. Accurately modelling long-term treatment response will aid prognostication at …
medications. Accurately modelling long-term treatment response will aid prognostication at …
Forecasting cycles of seizure likelihood
Objective Seizure unpredictability is rated as one of the most challenging aspects of living
with epilepsy. Seizure likelihood can be influenced by a range of environmental and …
with epilepsy. Seizure likelihood can be influenced by a range of environmental and …
A big data approach to the development of mixed‐effects models for seizure count data
Objective Our objective was to develop a generalized linear mixed model for predicting
seizure count that is useful in the design and analysis of clinical trials. This model also may …
seizure count that is useful in the design and analysis of clinical trials. This model also may …
Early follow-up data from seizure diaries can be used to predict subsequent seizures in same cohort by borrowing strength across participants
Accurate prediction of seizures in persons with epilepsy offers opportunities for both
precautionary measures and preemptive treatment. Previously identified predictors of …
precautionary measures and preemptive treatment. Previously identified predictors of …
Seizure forecasting and cyclic control of seizures
Epilepsy is a unique neurologic condition characterized by recurrent seizures, where
causes, underlying biomarkers, triggers, and patterns differ across individuals. The …
causes, underlying biomarkers, triggers, and patterns differ across individuals. The …
Characteristics of large patient‐reported outcomes: where can one million seizures get us?
V Ferastraoaru, DM Goldenholz, S Chiang… - Epilepsia …, 2018 - Wiley Online Library
Objective To analyze data from Seizure Tracker, a large electronic seizure diary, including
comparison of seizure characteristics among different etiologies, temporal patterns in …
comparison of seizure characteristics among different etiologies, temporal patterns in …
Prospective validation study of an epilepsy seizure risk system for outpatient evaluation
S Chiang, DM Goldenholz, R Moss, VR Rao… - …, 2020 - Wiley Online Library
Objective We conducted clinical testing of an automated Bayesian machine learning
algorithm (Epilepsy Seizure Assessment Tool [EpiSAT]) for outpatient seizure risk …
algorithm (Epilepsy Seizure Assessment Tool [EpiSAT]) for outpatient seizure risk …
How accurate do self‐reported seizures need to be for effective medication management in epilepsy?
Studies suggest that self‐reported seizure diaries suffer from 50% under‐reporting on
average. It is unknown to what extent this impacts medication management. This study used …
average. It is unknown to what extent this impacts medication management. This study used …