Epilepsy as a dynamic disease: A Bayesian model for differentiating seizure risk from natural variability

S Chiang, M Vannucci, DM Goldenholz, R Moss… - Epilepsia …, 2018 - Wiley Online Library
Objective A fundamental challenge in treating epilepsy is that changes in observed seizure
frequencies do not necessarily reflect changes in underlying seizure risk. Rather, changes in …

Is seizure frequency variance a predictable quantity?

DM Goldenholz, SR Goldenholz, R Moss… - Annals of clinical …, 2018 - Wiley Online Library
Background There is currently no formal method for predicting the range expected in an
individual's seizure counts. Having access to such a prediction would be of benefit for …

Markov modelling of treatment response in a 30-year cohort study of newly diagnosed epilepsy

HD Simpson, E Foster, Z Ademi, N Lawn, MJ Brodie… - Brain, 2022 - academic.oup.com
People with epilepsy have variable and dynamic trajectories in response to antiseizure
medications. Accurately modelling long-term treatment response will aid prognostication at …

Forecasting cycles of seizure likelihood

PJ Karoly, MJ Cook, M Maturana, ES Nurse… - …, 2020 - Wiley Online Library
Objective Seizure unpredictability is rated as one of the most challenging aspects of living
with epilepsy. Seizure likelihood can be influenced by a range of environmental and …

A big data approach to the development of mixed‐effects models for seizure count data

JJ Tharayil, S Chiang, R Moss, JM Stern… - …, 2017 - Wiley Online Library
Objective Our objective was to develop a generalized linear mixed model for predicting
seizure count that is useful in the design and analysis of clinical trials. This model also may …

Early follow-up data from seizure diaries can be used to predict subsequent seizures in same cohort by borrowing strength across participants

CB Hall, RB Lipton, H Tennen, SR Haut - Epilepsy & Behavior, 2009 - Elsevier
Accurate prediction of seizures in persons with epilepsy offers opportunities for both
precautionary measures and preemptive treatment. Previously identified predictors of …

Seizure forecasting and cyclic control of seizures

RE Stirling, MJ Cook, DB Grayden, PJ Karoly - Epilepsia, 2021 - Wiley Online Library
Epilepsy is a unique neurologic condition characterized by recurrent seizures, where
causes, underlying biomarkers, triggers, and patterns differ across individuals. The …

Characteristics of large patient‐reported outcomes: where can one million seizures get us?

V Ferastraoaru, DM Goldenholz, S Chiang… - Epilepsia …, 2018 - Wiley Online Library
Objective To analyze data from Seizure Tracker, a large electronic seizure diary, including
comparison of seizure characteristics among different etiologies, temporal patterns in …

Prospective validation study of an epilepsy seizure risk system for outpatient evaluation

S Chiang, DM Goldenholz, R Moss, VR Rao… - …, 2020 - Wiley Online Library
Objective We conducted clinical testing of an automated Bayesian machine learning
algorithm (Epilepsy Seizure Assessment Tool [EpiSAT]) for outpatient seizure risk …

How accurate do self‐reported seizures need to be for effective medication management in epilepsy?

D Goldenholz, BH Brinkmann, MB Westover - Epilepsia, 2024 - Wiley Online Library
Studies suggest that self‐reported seizure diaries suffer from 50% under‐reporting on
average. It is unknown to what extent this impacts medication management. This study used …