Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain
polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid …

Objective We examined the association between the ratio of serum eicosapentaenoic acid to
arachidonic acid (EPA/AA) or the docosahexaenoic acid (DHA)/AA and the development of …

Background Epidemiological and clinical evidence suggests that an increased intake of long-
chain n-3 fatty acids protects against mortality from coronary artery disease. We aimed to test …

Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids …

Numerous clinical trials have demonstrated the effects of oral preparations (fish oil and
purified ω3 fatty acids [ω3]) in preventing and treating various diseases. However, the effects …

HYPOTHESIS: The principle aim of the current study is to test the hypothesis that the long-
term use of highly purified EPA (eicosapentaenoic acid: 1800 mg/day), in addition to HMG …

Aim: The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized
clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid …

Background Omega-3 polyunsaturated fatty acids (PUFAs) have been a hot topic since the
Japan EPA Lipid Intervention Study (JELIS), the first landmark study using a highly purified …

Background: Results from JELIS (Japan EPA Lipid Intervention Study) demonstrated the
efficacy of pure eicosapentaenoic acid (EPA) in preventing coronary artery disease (CAD) in …

Inflammation is a normal process that is part of host defence and tissue healing. However,
excessive or unresolved inflammation can lead to uncontrolled tissue damage, pathology …