Background Prostate cancer continues to be the most common lethal malignancy diagnosed
in American men and the second leading cause of male cancer mortality. The American …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

The prostate is an androgen-dependent organ that develops only in male mammals.
Prostate cancer is the most common nonskin malignancy in men and the second leading …

Prostate carcinoma is the most frequently diagnosed malignancy and the second leading
cause of death as a result of cancer in men in the western countries. Withdrawal of …

Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …

Prostate cancer is the second most prevalent cancer in males in the United States. Standard
therapy relies on removing, or blocking the actions of, androgens. In most cases, this therapy …

Prostate cancer is the second leading cause of cancer-related deaths among men in North
America. Almost all prostate cancers begin in an androgen-dependent state, so androgen …

Prostate cancer remains one of the most commonly diagnosed cancers and a leading cause
of cancer death in men. Initially, prostate tumors respond to hormonal therapies, but …

This review is triggered by recent developments that offer new explanations for the
mechanism of progression of prostate cancer to androgen independence. Established and …

Most prostate cancers are androgen-sensitive malignancies whose growths depend on the
transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins …