The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is
mostly exported across mucous membranes. The discovery of IgA and the realization that it …

Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In
this review, we summarize recent advances in our understanding of the sites, mechanisms …

Immunoglobulin A (IgA) is the main secretory immunoglobulin of mucous membranes and is
powerfully induced by the presence of commensal microbes in the intestine. B cells undergo …

IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a
dimer across mucous membranes. This review discusses the different mechanisms of …

In mammals, the gut is populated with an extremely dense and diverse bacterial community.
One response following intestinal colonization is the production of immunoglobulin (Ig) A by …

Immunoglobulin A is the main element of the humoral immune response that has been
selected through evolution, together with innate mucosal defences, to provide protection …

The traditional role of IgA antibodies in mucosal defense has been considered as providing
an immune barrier to keep exogenous substances, including microbial pathogens, from …

The gut harbors an extremely dense and complex community of microorganisms that are in
constant dialog with our immune cells. The gut bacteria provide strong selective pressure to …

The intestine is undoubtedly the most misunderstood and under-appreciated lymphoid
organ in the body. Yet, in the eyes of mucosal immunologists, the gut exemplifies finely …

IgA is produced in large quantities at mucosal surfaces by IgA+ plasma cells (PC), protecting
the host from pathogens, and restricting commensal access to the subepithelium. It is …