Cocaine use disorder is a serious public health issue for which no approved
pharmacotherapies exist. The development of a pharmacotherapy for cocaine use disorder …

Drug self-administration procedures are the gold standard for laboratory research to study
mechanisms of drug use disorders and evaluate candidate medications. However …

Background Homologous cocaine self-administration procedures in laboratory animals and
humans may facilitate translational research for medications development to treat cocaine …

Individuals with cocaine use disorder chronically self-administer cocaine to the detriment of
other rewarding activities, a phenomenon best modeled in laboratory drug-choice …

Amphetamine maintenance is effective clinically to reduce the consumption of the
monoamine uptake inhibitor cocaine but not of the monoamine releaser methamphetamine …

An agonist approach to pharmacotherapy has been successful in treating abuse of several
drugs. Currently, no agonist therapy is available for cocaine addiction. Amphetamine, a …

Cocaine abuse results in disruption of dopamine (DA) system function, and it has been
postulated that this hypodopaminergic state underlies maladaptive behaviors in addiction …

Background A medication for treating cocaine use disorder has yet to be approved.
Laboratory-based evaluation of candidate medications in animals and humans is a valuable …

Opinion statement Drug addiction is a disease that manifests as an inappropriate allocation
of behavior towards the procurement and use of the abused substance and away from other …

Human drug use involves repeated choices to take drugs or to engage in alternative
behaviors. The purpose of this study was to examine how response cost for cocaine and the …