Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential
for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells …

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is now routinely
accomplished by overexpression of the four Yamanaka factors (OCT4, SOX2, KLF4, MYC (or …

Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues,
may particularly benefit older patients, who are more likely to suffer from degenerative …

Oct4 is widely considered the most important among the four Yamanaka reprogramming
factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for …

The generation of induced pluripotent stem cells (iPSCs) by the forced expression of defined
transcription factors in somatic cells holds great promise for the future of regenerative …

The role of Yamanaka factors as the core regulators in the induction of pluripotency during
somatic cell reprogramming has been discovered recently. Our previous study found that …

Ever since the creation of induced pluripotent cells (iPSCs) from adult somatic cells by the
ectopic expression of defined transcription factors [1, 2], whether iPS cells are equivalent to …

Here, we provide data suggesting that the absence of silencing of the ectopic
reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells …

Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is
inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

Pluripotent stem cells, having self-renewal capacities and multi-lineage differentiation
abilities, offer great potential in disease modeling and therapeutic applications. The …