Tissue-resident memory T cells populate the human brain

J Smolders, KM Heutinck, NL Fransen… - Nature …, 2018 - nature.com
Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

The molecular signature of tissue resident memory CD8 T cells isolated from the brain

LM Wakim, A Woodward-Davis, R Liu, Y Hu… - The Journal of …, 2012 - journals.aai.org
Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell
population. We have previously characterized a population of Trm cells that persists within …

Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites

BV Kumar, W Ma, M Miron, T Granot, RS Guyer… - Cell reports, 2017 - cell.com
Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to
infection and vaccination, while in humans, the existence and properties of TRMs remain …

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

SL Urban, IJ Jensen, Q Shan, LL Pewe, HH Xue… - Nature …, 2020 - nature.com
The central nervous system (CNS) is classically viewed as immune-privileged; however,
recent advances highlight interactions between the peripheral immune system and CNS in …

Local immunity by tissue-resident CD8+ memory T cells

T Gebhardt, LK Mackay - Frontiers in immunology, 2012 - frontiersin.org
Microbial infection primes a CD8+ cytotoxic T cell response that gives rise to a long-lived
population of circulating memory cells able to provide protection against systemic …

CD4+ memory T cells at home in the tissue: mechanisms for health and disease

D Schreiner, CG King - Frontiers in immunology, 2018 - frontiersin.org
During the last 10 years, a population of clonally expanded T cells that take up permanent
residence in non-lymphoid tissues has been identified. The localization of these tissue …

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

JJ Milner, H Nguyen, K Omilusik… - Proceedings of the …, 2020 - National Acad Sciences
Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

JT Crowl, M Heeg, A Ferry, JJ Milner, KD Omilusik… - Nature …, 2022 - nature.com
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

MM Klicznik, PA Morawski, B Höllbacher… - Science …, 2019 - science.org
Tissue-resident memory T cells (TRM) persist locally in nonlymphoid tissues where they
provide frontline defense against recurring insults. TRM at barrier surfaces express the …

Tissue-resident T cells and other resident leukocytes

D Masopust, AG Soerens - Annual review of immunology, 2019 - annualreviews.org
Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …