Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence
A Isaev, A Drobiazko, N Sierro, J Gordeeva… - Nucleic acids …, 2020 - academic.oup.com
BREX (for BacteRiophage EXclusion) is a superfamily of common bacterial and archaeal
defence systems active against diverse bacteriophages. While the mechanism of BREX …
defence systems active against diverse bacteriophages. While the mechanism of BREX …
Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system
YA Luyten, DE Hausman, JC Young… - Nucleic acids …, 2022 - academic.oup.com
Abstract Bacteriophage exclusion ('BREX') phage restriction systems are found in a wide
range of bacteria. Various BREX systems encode unique combinations of proteins that …
range of bacteria. Various BREX systems encode unique combinations of proteins that …
BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site
J Gordeeva, N Morozova, N Sierro, A Isaev… - Nucleic acids …, 2019 - academic.oup.com
Prokaryotes evolved numerous systems that defend against predation by bacteriophages. In
addition to well-known restriction-modification and CRISPR-Cas immunity systems, many …
addition to well-known restriction-modification and CRISPR-Cas immunity systems, many …
BREX is a novel phage resistance system widespread in microbial genomes
T Goldfarb, H Sberro, E Weinstock, O Cohen… - The EMBO …, 2015 - embopress.org
The perpetual arms race between bacteria and phage has resulted in the evolution of
efficient resistance systems that protect bacteria from phage infection. Such systems, which …
efficient resistance systems that protect bacteria from phage infection. Such systems, which …
DISARM is a widespread bacterial defence system with broad anti-phage activities
The evolutionary pressure imposed by phage predation on bacteria and archaea has
resulted in the development of effective anti-phage defence mechanisms, including …
resulted in the development of effective anti-phage defence mechanisms, including …
The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses
DM Picton, YA Luyten, RD Morgan… - Nucleic acids …, 2021 - academic.oup.com
Bacteria have evolved a multitude of systems to prevent invasion by bacteriophages and
other mobile genetic elements. Comparative genomics suggests that genes encoding …
other mobile genetic elements. Comparative genomics suggests that genes encoding …
Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
A Andriianov, S Trigüis, A Drobiazko, N Sierro… - Cell Reports, 2023 - cell.com
Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine
(SAM), circumvents the SAM-dependent type I restriction-modification (RM) defense. We …
(SAM), circumvents the SAM-dependent type I restriction-modification (RM) defense. We …
Bacteriophage exclusion, a new defense system
R Barrangou, J Van Der Oost - The EMBO Journal, 2015 - embopress.org
The ability to withstand viral predation is critical for survival of most microbes. Accordingly, a
plethora of phage resistance systems has been identified in bacterial genomes (Labrie et al …
plethora of phage resistance systems has been identified in bacterial genomes (Labrie et al …
Phage T4-coded Stp: double-edged effector of coupled DNA and tRNA-restriction systems
M Penner, I Morad, L Snyder, G Kaufmann - Journal of molecular biology, 1995 - Elsevier
The optionalEscherichia coli prrlocus encodes two physically associated restriction systems:
the type IC DNA restriction-modification enzymeEcoprrI and the tRNALys-specific anticodon …
the type IC DNA restriction-modification enzymeEcoprrI and the tRNALys-specific anticodon …
Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor
BW Shen, LA Doyle, R Werther… - Nucleic Acids …, 2023 - academic.oup.com
Abstract Bacteriophage exclusion ('BREX') systems are multi-protein complexes encoded by
a variety of bacteria and archaea that restrict phage by an unknown mechanism. One BREX …
a variety of bacteria and archaea that restrict phage by an unknown mechanism. One BREX …