The latest advances in the discovery of nitric oxide hybrid drug compounds

RAM Serafim, FG Pernichelle… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: There is a great interest in Nitric oxide (NO) within medicinal chemistry since it's
involved in human signaling pathways. Prodrugs or hybrid compounds containing NO-donor …

Recent developments in drug design of NO-donor hybrid compounds

R Sharma, J Joubert, SF Malan - Mini Reviews in Medicinal …, 2018 - ingentaconnect.com
The free radical nitric oxide (NO) is considered one of the most versatile endogenous
molecules and is a crucial signalling molecule in numerous biochemistry pathways of the …

When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues

E Muniz Carvalho, EH Silva Sousa… - European Journal of …, 2021 - Wiley Online Library
Nitric oxide (NO.) has been widely studied as an active agent of many physiological and
pathological processes. Currently, NO. divides attention with its sibling molecule, nitroxyl …

Nitric oxide: state of the art in drug design

RAM Serafim, MC Primi, GHG Trossini… - Current medicinal …, 2012 - ingentaconnect.com
Since the great discovery of Furchgott, Ignarro and Murad in the late 90's, nitric oxide (NO) is
considered one of the most versatile endogenous molecules, which is involved in important …

Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications

Y Yang, Z Huang, LL Li - Nanoscale, 2021 - pubs.rsc.org
Nitric oxide (NO), as an endogenous diatomic molecule, plays a key regulatory role in many
physiological and pathological processes. This diatomic free radical has been shown to …

Nitric oxide donors-current trends in therapeutic applications

J Lehmann - Expert Opinion on Therapeutic Patents, 2000 - Taylor & Francis
The nitric oxide (NO) radical, endogenously produced from L-arginine, is a natural
vasodilator also involved in many other physiological and pathological processes. The …

Recent developments in nitric oxide donor drugs

MR Miller, IL Megson - British journal of pharmacology, 2007 - Wiley Online Library
During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial
signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune …

Pharmacological modulation of nitric oxide release: new pharmacological perspectives, potential benefits and risks

R Scatena, P Bottoni, A Pontoglio… - Current medicinal …, 2010 - ingentaconnect.com
Nitric oxide is becoming an increasingly important signalling molecule implicated in a
growing number of physiological and pathophysiological processes. Moreover, with the …

Nitric-oxide releasing molecules: a new class of drugs with several major indications

JL Burgaud, JP Riffaud… - Current pharmaceutical …, 2002 - ingentaconnect.com
Nitric oxide (NO) deficiency has been implicated in many pathological and physiological
processes within the mammalian body providing a plausible biologic basis for the use of NO …

Nitric oxide‐releasing drugs: a novel class of effective and safe therapeutic agents

JLUC BURGAUD, E Ongini… - Annals of the New York …, 2002 - Wiley Online Library
Nitric oxide (NO) deficiency has been implicated in many pathologic processes, thus
providing a solid biological basis for the use of NO replacement therapy. Exogenous NO …