The main physiological challenge in high altitude environment is hypoxia which affects the
aerobic metabolism reducing the energy supply. These changes may further progress …

Abstract Lou, Bih-Show, Pei-Shan Wu, Yitong Liu, and Jong-Shyan Wang. Effects of acute
systematic hypoxia on human urinary metabolites using LC-MS-based metabolomics. High …

High altitude medicine is an emerging subspecialty that has crosscutting relevance for 21st
century science and society: from sports medicine and aerospace industry to urban and rural …

The exposure of healthy subjects to high altitude represents a model to explore the
pathophysiology of diseases related to tissue hypoxia. We explored a plasma metabolomics …

Knowledge on metabolites distinguishing the metabolic response to acute physical exercise
between fit and less fit individuals could clarify mechanisms and metabolic pathways …

Metabolomics is a comprehensive method for metabolite assessment that involves
measuring the overall metabolic signature of biological samples. We used this approach to …

Serum samples from eight participants during the XV winter-over at Concordia base
(Antarctic expedition) collected at defined time points, including predeparture, constituted …

It is consensus in the metabolomics community that standardized protocols should be
followed for sample handling, storage and analysis, as it is of utmost importance to maintain …

When ascending to high altitude, it is a rigorous challenge to people who living in the low
altitude area to acclimatize to hypoxic environment. Hypoxia exposure can cause dramatic …

Individuals sojourning at high altitude (≥ 2,500 m) often develop acute mountain sickness
(AMS). However, substantial unexplained inter-individual variability in AMS severity exists …