De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo

H Fang, S Yao, Q Chen, C Liu, Y Cai, S Geng, Y Bai… - ACS …, 2019 - ACS Publications
As the cleaners of cells, lysosomes play an important role in circulating organic matter within
cells, recovering damaged organelles, and removing waste via endocytosis. Because …

Ultralong-term super-resolution tracking of lysosomes in brain organoids by near-infrared noble metal nanoclusters

K Qiu, A Yadav, Z Tian, Z Guo, D Shi… - ACS Materials …, 2022 - ACS Publications
To study lysosomes with an ultralong term, herein, noble-metal Au and Ag nanoclusters
(MNCs) modified with biocompatible protein bovine serum albumin (BSA) called BSA–NCs …

Phosphole-oxide-based fluorescent probe for super-resolution stimulated emission depletion live imaging of the lysosome membrane

C Wang, M Taki, K Kajiwara, J Wang… - ACS Materials …, 2020 - ACS Publications
Super-resolution imaging techniques have become increasingly important tools to visualize
suborganelle structures and dynamic processes in living cells on the nanoscale. However …

Surpassing the background barrier for multidimensional single-molecule localization super-resolution imaging: a case of lysosome-exclusively turn-on probe

Z Ye, Y Zheng, X Peng, Y Xiao - Analytical Chemistry, 2022 - ACS Publications
The background barrier restricts the dimensionality of live-cell single-molecule localization
super-resolution imaging. Ideally, a probe exclusively turned on by its target, without any …

Super-resolution fluorescent materials: an insight into design and bioimaging applications

Z Yang, A Sharma, J Qi, X Peng, DY Lee… - Chemical Society …, 2016 - pubs.rsc.org
Living organisms are generally composed of complex cellular processes which persist only
within their native environments. To enhance our understanding of the biological processes …

Red AIE luminogens with tunable organelle specific anchoring for live cell dynamic super resolution imaging

Z Lv, Z Man, H Cui, Z Xu, H Cao, S Li… - Advanced Functional …, 2021 - Wiley Online Library
Lysosomes and mitochondria play an important role in maintaining cell homeostasis.
Visualizing the long‐term activities of lysosomes and mitochondria on the nanometer scale …

An Acid‐Regulated Self‐Blinking Fluorescent Probe for Resolving Whole‐Cell Lysosomes with Long‐Term Nanoscopy

Q Qiao, W Liu, J Chen, X Wu, F Deng… - Angewandte …, 2022 - Wiley Online Library
Long‐term super‐resolution imaging appears to be increasingly important for unraveling
organelle dynamics at the nanoscale, but is challenging due to the need for highly …

Nanoparticles for super-resolution microscopy and single-molecule tracking

D Jin, P Xi, B Wang, L Zhang, J Enderlein… - Nature …, 2018 - nature.com
We review the use of luminescent nanoparticles in super-resolution imaging and single-
molecule tracking, and showcase novel approaches to super-resolution imaging that …

[HTML][HTML] Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles

K Qiu, Y Du, J Liu, JL Guan, H Chao, J Diao - Theranostics, 2020 - ncbi.nlm.nih.gov
Because lysosomes play critical roles in multiple cellular functions and are associated with
many diseases, studying them at the subcellular level could elucidate their functionality and …

Water-soluble polymeric photoswitching dyads impart super-resolution lysosome highlighters

C Li, Z Hu, MP Aldred, LX Zhao, H Yan… - …, 2014 - ACS Publications
In this report, we integrated a photoswitchable quencher, a highly emissive yet pH sensitive
fluorophore, and a water-soluble polymer with controlled hydrophilicity into a functional …