Objective While there are several trials that support the efficacy of various drugs for migraine
prophylaxis against placebo, there is limited evidence addressing the comparative safety …

Objective To compare the effectiveness and side effects of migraine prophylactic
medications. Design We performed a network meta-analysis. Data were extracted …

Background A large number patients struggle with migraine which is classified as a chronic
disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine …

Objective The aim of this paper is to critically re-appraise the published trials assessing
amitriptyline for migraine prophylaxis. Methods We report our methods and results following …

Background Over the last six decades (earliest included publication from 1959), clinical trials
of migraine preventive treatments have led to the regulatory approval of many medications …

Objective Novel disease-specific and mechanism-based treatments sharing good evidence
of efficacy for migraine have been recently marketed. However, reimbursement by insurers …

Objectives: The primary objective of this guideline is to assist the practitioner in choosing an
appropriate prophylactic medication for an individual with migraine, based on current …

To quantify the placebo response of prophylactic therapy in migraine, a meta-analysis of
prophylactic, double-blind, placebo controlled migraine studies was performed. The total …

Introduction Migraine prophylactic therapy has changed over recent years with the
development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene …

Objectives: In order to understand the pattern of utilization of migraine prophylactic drugs by
US physicians, we reviewed the scientific rigor of published trials of anti‐migraine …