Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs
(eg, dexamethasone) cause undesirable side effects that are features of the metabolic …

GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary
carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase …

Liver X receptor (LXR), a nuclear hormone receptor, is an essential regulator of immune
responses. Activation of LXR-mediated transcription by synthetic agonists, such as …

Liver X receptors (LXRs) α and β are nuclear receptors whose transcriptional activity is
regulated by oxysterols, the oxidized forms of cholesterol. Described in the late 1990s as …

Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the
metabolic syndrome is unclear. We show that LXRs modulate key aspects of the metabolic …

Liver X receptor (LXR) α expression is mainly localized to metabolic tissues, such as the
liver, whereas LXR β is ubiquitously expressed. LXR α is activated by oxysterols and plays …

The nuclear hormone receptors liver X receptor α (LXRα)(NR1H3) and LXRβ (NR1H2) are
established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug …

The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated
by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively …