A molecular simplification approach of previously reported 2-arylpyrazolo [3, 4-c] quinolin-4-
ones was applied to design 2-arylpyrazolo [4, 3-d] pyrimidin-7-one derivatives as new …

In previous research, we identified some 7-oxo-and 7-acylamino-substituted pyrazolo [4, 3-
d] pyrimidine derivatives as potent and selective human (h) A 3 adenosine receptor (AR) …

On the basis of our previously reported 2-arylpyrazolo [4, 3-d] pyrimidin-7-ones, a set of 2-
arylpyrazolo [4, 3-d] pyrimidin-7-amines were designed as new human (h) A3 adenosine …

The paper describes a new class of human (h) A3 adenosine receptor antagonists, the 2-
arylpyrido [2, 3-e]-1, 2, 4-triazolo [4, 3-a] pyrazin-1-one derivatives (PTP), either 4-oxo (1− 6 …

The study of novel 2-arylpyrazolo [3, 4-c] quinolin-4-(hetero) arylamides, designed as
human (h) A3 adenosine receptor antagonists, is reported. The new derivatives are …

A new series of 7-aminopyrazolo [4, 3-d] pyrimidine derivatives (1–31) were synthesized to
evaluate some structural modifications at the 2-and 5-positions aimed at shifting affinity …

Among the heterocyclic structures identified as potent human A3 (hA3) adenosine receptor's
antagonists, we have demonstrated that the new pyrazolo-triazolo-pyrimidines, bearing an …

Here we describe the design and synthesis of pyrazolo [3, 4-d] pyridazines as adenosine
receptor (AR) ligands. We demonstrate that the introduction of a 3-phenyl group, together …

A structural investigation on some 4-amido-2-phenyl-1, 2-dihydro-1, 2, 4-triazolo [4, 3-a]
quinoxalin-1-one derivatives, designed as human A3 adenosine receptor (hA3 AR) …

In previous research, several 7-amino-2-arylpyrazolo [4, 3-d] pyrimidine derivatives were
identified as highly potent and selective antagonists at the human A 3 adenosine receptor …