Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention

MF McCarty - Medical hypotheses, 2012 - Elsevier
A recent meta-analysis examining long-term mortality in subjects who participated in
controlled studies evaluating the impact of daily aspirin on vascular risk, has concluded that …

Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?

RE Langley, S Burdett, JF Tierney, F Cafferty… - British journal of …, 2011 - nature.com
Aspirin inhibits the enzyme cyclooxygenase (Cox), and there is a significant body of
epidemiological evidence demonstrating that regular aspirin use is associated with a …

Chemopreventive effects of aspirin at a glance

MW Usman, F Luo, H Cheng, JJ Zhao, P Liu - Biochimica et Biophysica …, 2015 - Elsevier
Experimental, epidemiological, and clinical data from the last two decades have each
supported the hypothesis that aspirin possesses anticancer properties, and that its use may …

Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade

RE Harris, J Beebe-Donk, H Doss… - Oncology …, 2005 - spandidos-publications.com
We comprehensively reviewed the published scientific literature on non-steroidal anti-
inflammatory drugs (NSAIDs) and cancer and evaluated results based upon epidemiologic …

[引用][C] Aspirin as a treatment for cancer

I Phillips, R Langley, D Gilbert… - Clinical …, 2013 - clinicaloncologyonline.net
Over the last 2 years, data from prospective trials have consolidated the pre-existing
evidence from epidemiological and observational studies that suggest that aspirin has …

Cancer prevention: a new era beyond cyclooxygenase-2

B Rigas, K Kashfi - Journal of Pharmacology and Experimental …, 2005 - ASPET
The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

Pharmacologic effects of NSAIDs and implications for the risks and benefits of long-term prophylactic use of aspirin to prevent cancer

MJ Thun, B Blackard - Cancer Prevention II, 2009 - Springer
This paper briefly reviews the pharma-cologic effects of nonsteroidal antiinflammatory drugs
(NSAIDs) that influence the risks and benefits of using these drugs prophylactically for …

COX-2 inhibitors in cancer treatment and prevention, a recent development

XC Xu - Anti-cancer drugs, 2002 - journals.lww.com
Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

The role of aspirin in cancer prevention

MJ Thun, EJ Jacobs, C Patrono - Nature reviews Clinical oncology, 2012 - nature.com
Clinical guidelines for prophylactic aspirin use currently only consider the cardiovascular
benefits of aspirin, weighed against the potential harm from aspirin-induced bleeding. Daily …

An aspirin a day: new pharmacological developments and cancer chemoprevention

DG Menter, RS Bresalier - Annual Review of Pharmacology and …, 2023 - annualreviews.org
Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent the progression or recurrence of cancer. A large body of preclinical and clinical data …