[HTML][HTML] Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex

B Chruścicka, CSM Cowan, SEW Fitzsimons… - …, 2021 - Elsevier
The complexity of oxytocin-mediated functions is strongly associated with its modulatory
effects on other neurotransmission systems, including the serotonin (5-hydroxytryptamine, 5 …

Attenuation of oxytocin and serotonin 2A receptor signaling through novel heteroreceptor formation

B Chruscicka, SE Wallace Fitzsimons… - ACS Chemical …, 2019 - ACS Publications
The oxytocin receptor (OTR) and the 5-hydroxytryptamine 2A receptor (5-HTR2A) are
expressed in similar brain regions modulating central pathways critical for social and …

[HTML][HTML] The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior

DO Borroto-Escuela, C Cuesta-Marti… - Frontiers in Molecular …, 2022 - frontiersin.org
In the last 10 years, it has become increasingly clear that large numbers of axon collaterals
extend from the oxytocin (OXT) hypothalamic axons, especially the parvocellular …

Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors

M Busnelli, E Bulgheroni, M Manning, G Kleinau… - … of Pharmacology and …, 2013 - ASPET
The neuropeptides oxytocin (OT) and vasopressin (AVP) have been shown to play a central
role in social behaviors; as a consequence, they have been recognized as potential drugs to …

The oxytocin receptor

T Kimura, R Ivell - Regulatory Peptides and Cognate Receptors, 1999 - Springer
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the
rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the …

Role of oxytocin in parental behaviour

DE Olazábal - Journal of neuroendocrinology, 2018 - Wiley Online Library
Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts
in the brain (eg, medial preoptic area, ventral tegmental area, nucleus accumbens) to …

Molecular basis of oxytocin receptor signalling in the brain: what we know and what we need to know

M Busnelli, B Chini - Behavioral pharmacology of neuropeptides: Oxytocin, 2018 - Springer
Oxytocin (OT), a hypothalamic neuropeptide involved in regulating the social behaviour of
all vertebrates, has been proposed as a treatment for a number of neuropsychiatric …

The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2

GK Tóth, K Bakos, B Penke, I Pávó, C Varga… - Bioorganic & medicinal …, 1999 - Elsevier
Analogues of oxytocin containing D-Trp, 2-amino-1, 2, 3, 4-tetrahydronaphthalene-1-
carboxylic acid (Atc) or 1, 2, 3, 4-tetrahydro-β-carboline-1-carboxylic acid (Car) with R or S …

Introduction of a cis-Prolyl Mimic in Position 7 of the Peptide Hormone Oxytocin Does Not Result in Antagonistic Activity

A Wittelsberger, L Patiny, J Slaninova… - Journal of medicinal …, 2005 - ACS Publications
New insights into the structure− activity relationship of the peptide hormone oxytocin are
presented. Incorporation of the novel cis-prolyl mimic 2, 2-dimethyl-1, 3-thiazolidine-4 …