Many vaccines induce protective immunity via antibodies. Systems biology approaches
have been used to determine signatures that can be used to predict vaccine-induced …

Abstract Systems vaccinology has defined molecular signatures and mechanisms of
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …

Vaccines have drastically reduced the mortality and morbidity of many diseases. However,
vaccines have historically been developed empirically, and recent development of vaccines …

Homo sapiens are genetically diverse, but dramatic demographic and socioeconomic
changes during the past century have created further diversification with respect to age …

Systems approaches have been used to describe molecular signatures driving immunity to
influenza vaccination in humans. Whether such signatures are similar across multiple …

A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we
have used a systems biology approach to identify early gene'signatures' that predicted …

Systems immunology approaches were employed to investigate innate and adaptive
immune responses to influenza and pneumococcal vaccines. These two non-live vaccines …

Vaccines represent a potent tool to prevent or contain infectious diseases with high
morbidity or mortality. However, despite their widespread use, we still have a limited …

The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …

Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that …